Emerging Functions of Amphiregulin in Orchestrating Immunity ...
WEBFeb 17, 2015 · In this review, we will summarize recent developments regarding the distribution and regulation of AREG expression in the steady-state and during inflammation. We will then discuss the role of AREG in resistance and tolerance to a variety of pathogens, in promotion of tissue repair and in the regulation of tumor progression.
Amphiregulin in infectious diseases: Role, mechanism, and …
WEBJan 1, 2024 · The observed association between the expression of AREG and the M2 macrophage phenotype indicates that signaling pathways associated with M2 polarization may promote the expression of AREG in macrophages.
Amphiregulin - PubMed
WEBAmphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells.
Sustained amphiregulin expression in intermediate alveolar stem …
WEBSep 5, 2024 · Sustained elevation of AREG from intermediate alveolar stem cells drives progressive lung fibrosis. In this study, we unveiled the pivotal role of sustained AREG expression from intermediate alveolar stem cells (AT2 …
AREG Gene - GeneCards | AREG Protein | AREG Antibody
WEBAug 5, 2024 · The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha).
Amphiregulin in cellular physiology, health, and disease ... - PubMed
WEBIn this review, we discuss the structure, function, and regulation of AREG, its role in tissue repair, inflammation, and homeostasis as well as the potential of AREG as a biomarker and therapeutic target.
Amphiregulin - ScienceDirect
WEBApr 1, 2014 · Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage …
Amphiregulin normalizes altered circuit connectivity for social ...
WEBSep 20, 2023 · In the brain, it is involved in cognition, memory formation, addiction, anxiety, and depression in part through the regulation of phosphorylation-dependent modulation of cAMP-responsive...
Targeting autocrine amphiregulin robustly and reproducibly inhibits ...
WEBApr 30, 2021 · In immunocompetent animals, depletion or overexpression of AREG respectively prolonged or shortened animal survival. A new antibody we generated in AREG-knockout mice recognized murine AREG...
Amphiregulin in lung diseases: A review - PMC - National Center …
WEBFeb 2, 2024 · As we all know, AREG is a member of the EGF family, its function is mainly mediated through binding and activating EGFR, a widely expressed tyrosine kinase receptor with 4 types, named ErbB1, ErbB2, ErbB3, and ErbB4.