Christian McCaffrey's injury against the Bills could be due to the heavy workload he received since returning to the 49ers.

49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury ...

The San Francisco 49ers on Tuesday announced how they’d replace running back Christian McCaffrey. In a slew of roster moves ...

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve Tuesday a day after coach Kyle Shanahan ...

SANTA CLARA, Calif. — San Francisco 49ers running back Christian McCaffrey likely suffered a partial tear of his posterior ...

The San Francisco 49ers aren't in the position they want to be right now and it seems like this just isn't their year.

The San Francisco 49ers have promoted RB Patrick Taylor Jr. to the active roster from the team's practice squad and placed DL ...

The San Francisco 49ers are moving forward without star running back Christian McCaffrey or backup Jordan Mason for the ...

The San Francisco 49ers and fantasy football players who were relying on the NFC West team's running backs are probably all ...

NFL season appears to be over for Christian McCaffrey, which is why the San Francisco 49ers have added two new running backs ...

San Francisco picked up running back Israel Abanikanda off waivers from the Jets after a slew of injuries in their backfield.

San Francisco 49ers star running back Christian McCaffrey has battled injuries all season, but now he has suffered a PCL ...