Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

Here are the Week 13 games that will impact the 49ers’ playoff chances and which team the 49ers need to win: 49ers need: A ...

Here are the full injury reports for the Buffalo Bills and San Francisco 49ers ahead of their Week 13 matchup at Highmark ...

The Buffalo Bills might have a chance to clinch the AFC East on Sunday night when they battle the injury-decimated San ...

Speaking with reporters on Wednesday, San Francisco 49ers head coach Kyle Shanahan says it's "unfair" to expect running back ...

Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...

The Buffalo Bills (9-2) are moving on to their their Week 13 contest against the San Francisco 49ers (5-6). Prior to that, ...

Upon re-joining the Bills, Phillips brought back his long-standing tradition. In the past during practice, Phillips has worn ...

One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's ...

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio ...